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| Antigenic Specificity | CD11/CD18 |
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| Clone | 24 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | fluorescein (FITC) conjugate |
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| Size | 50ul |
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| Concentration | 0.9mg/ml |
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| Applications | Flow cyt, ICC/IF |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mouse anti CD11/CD18 [24]: Fluorescein. This antibody recognises integrin alpha L,M,X/Beta 2 (CD11/CD18). Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits which mediate cell-cell and cell-extracellular matrix attachments. Integrin beta2 (CD18) associates with integrin alpha L (CD11a) to form the leukocyte function-associated antigen-1 (LFA-1) with integrin alpha M (CD11b) to form Complement Receptor 3 (CR3) and with integrin alpha X (CD11c) to form Complement Receptor 4 (CR4). Each integrin receptor can bind various Intercellular adhesion molecules (ICAMs). Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. |
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| Immunogen | Fibronectin-purified human monocytes |
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| Other Names | Integrin alpha (L, M, X)/beta 2 |
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| Gene, Accession # | n/a |
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| Catalog # | IQ639FITC |
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| Price | |
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| Order / More Info | CD11/CD18 Antibody from IMMUQUEST LTD. |
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| Product Specific References | Hogg N, et al. An anti-human monocyte/macrophage monoclonal antibody, reacting most strongly with macrophages in lymphoid tissue. Cell Immunol. 1985. 92(2):247-53. PMID:2581704 http://www.ncbi.nlm.nih.gov/pubmed/2581704 |
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