| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Product Name | LY 404187 |
|---|
| Description | Selective AMPA receptor positive allosteric modulator (IC50 values are 0.15, 0.21, 1.66 and 5.65 μM for GluA2i, GluA4i, GluA3i and GluA1i respectively). Potentiates glutamate and AMPA-evoked currents in pre frontal cortex (PFC) pyramidal neurons in vitro. Has no effect on NMDA- or kainate-evoked currents; also has no effect on K+ or Na+ ion channels. Potentiates PFC glutamatergic synaptic transmission in vitro and in vivo. Induces neurite growth in combination with (S)-AMPA (Cat. No. 0254) in SH-SY5Y human neuroblastoma cells in vitro. Also reduces MPTP-induced toxicity in mice. Brain penetrant. Purity 98%. MW (observed): 342.46 |
|---|
| Size | 10 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide |
|---|
| Gene, Accession, CAS # | CAS: 211311-95-4 |
|---|
| Catalog # | 5297/10 |
|---|
| Price | |
|---|
| Order / More Info | LY 404187 from TOCRIS BIOSCIENCE
|
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|