| 產(chǎn)品詳情 |
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| Product Name | A-419259 |
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| Description | An inhibitor of Src family kinases, including Src, LCK, Lyn, and Hck (IC50s = 9, 50 = 3,000 nM) and PKC (IC50 = >33 μM); inhibits growth of Ph+ K-562 and Meg-01 myeloid leukemia cells (IC50s = 0.1-0.3 and 0.1 μM, respectively), but not Ph- TF-1 and HEL cells; induces apoptosis in K-562 cells in a concentration-dependent manner; inhibits differentiation of murine embryonic stem cells while maintaining pluripotency at 300 nM; reduces the total number of AML cells, as well as AML stem cells, in the bone marrow and spleen of human patient-derived AML mouse xenograft models at 30 mg/kg twice daily |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | RK-20449 |
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| Gene, Accession, CAS # | CAS: 364042-47-7 |
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| Catalog # | 25605-5 |
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| Order / More Info | A-419259 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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