| 產(chǎn)品詳情 |
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| Product Name | Apilimod mesylate |
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| Description | Apilimod is a small molecule that inhibits IL-12 and IL-23 production - cytokines that are involved in autoimmune diseases through the prevention of nuclear translocation of c-Rel. It suppresses the Th1, but not the Th2, response, resulting in reduced inflammation in a mouse model of inflammatory bowel disease. Apilimod inhibits the production of IL-23p19 and IL-12/IL-23p40 subunits while decreasing skin inflammation in a clinical study of patients with psoriasis. Apilimod inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve; IC50 = 14 nM), which is necessary and sufficient for suppression of IL-12/IL-23p40 expression. MW: 610.7. Purity ≥98% by HPLC |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (E)-4-(6-(2-(3-methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate |
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| Gene, Accession, CAS # | CAS: 870087-36-8 |
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| Catalog # | B1129-25 |
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| Price | |
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| Order / More Info | Apilimod mesylate from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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