| 產(chǎn)品詳情 |
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| Product Name | Interleukin 4 (IL4) (AA 25-153) (Active) protein |
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| Description | Interleukin-4 (IL-4) is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. It has important effects on the growth and differentiation of different immunologically competent cells. Interleukin-4 is produced by mast cells, T cells, and bone marrow stromal cells[1]. IL-4 regulates the differentiation of native CD4+ T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. IL-4 has numerous important biological functions including stimulating B-cells activation, T-cell proliferation and CD4+ T-cells differentiation to Th2 cells. It is a key regulator in hormone control and adaptive immunity[2]. IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells[3]. IL-4 is stabilized by three disulphide bonds forming a compact globular protein structure[4]. Four alpha-helix bundle with left-handed twist is dominated half of the protein structure with 2 overhand connections and fall into a 2-stranded anti-parallel beta sheet[5].Recombinant human IL-4 (rhIL-4) is a 129 amino acid protein expressed in mammalian CHO system. The approximate molecular weight is 15 kDa analyzed by non-reducing SDS-PAGE.Synonyms: IL-4, B cell growth factor-1 (BCGF-1), B cell stimulatory factor-1 (BSF-1), B cell differentiation factor (BCDF), T cell growth factor-2 (TCGF-2), Mast-cell growth factor-2 (MCGF-2) |
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| Size | 10 μg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL4|IL-4|BCGF-1|BCGF1|BSF-1|BSF1|Il-4|Il4e12|IL2 |
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| Gene, Accession, CAS # | Gene ID: 3565 |
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| Catalog # | ABIN2018116 |
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| Price | |
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| Order / More Info | Interleukin 4 (IL4) (AA 25-153) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 1993171, 21682751, 2096469, 12511873, 1400355 |
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