| 產(chǎn)品詳情 |
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| Antigenic Specificity | ATF6beta |
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| Clone | W17035A |
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| Host Species | Rat |
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| Reactive Species | human |
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| Isotype | IgG2b, κ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), ICC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-ATF6β. ATF6 encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells from ER stress. Under conditions of ER stress, ATF6 is transported from the ER to the Golgi apparatus, where it is cleaved by Golgi-resident proteases to release the cytosolic DNA-binding portion. Then the processed ATF6 moves to the nucleus to activate gene expression. Deletion of the isoform activating transcription factor 6α (ATF6α) and its paralog ATF6β results in embryonic lethality and notochord dysgenesis in nonhuman vertebrates, and loss-of-function mutations in ATF6α are associated with malformed neuroretina and congenital vision loss in humans. Altered ATF6 function in neurodegenerative disorders such as ?Parkinson's disease has been observed.? |
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| Immunogen | Human ATF6β recombinant protein (1-250 a.a.) expressed in E. coli. |
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| Other Names | Cyclic AMP-dependent transcription factor ATF-6 beta, ATF-6 beta, Activating transcription factor 6 beta, ATF6-beta |
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| Gene, Accession # | Gene ID: 1388 |
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| Catalog # | 853202 |
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| Price | |
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| Order / More Info | ATF6beta Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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