| Edit |   |
|---|
| Antigenic Specificity | ITM2B |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 μl |
|---|
| Concentration | n/a |
|---|
| Applications | Immunocytochemistry: 1-4 μg/mL, Immunofluorescence: 1-4 μg/mL |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | ITM2B Polyclonal Antibody. Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. |
|---|
| Immunogen | n/a |
|---|
| Other Names | ITM2B; integral membrane protein 2B; ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; BRICHOS domain containing 2B; OTTHUMP00000018394 |
|---|
| Gene, Accession # | Entrez: 9445; Uniprot: Q9Y287 |
|---|
| Catalog # | PA5-67219 |
|---|
| Price | |
|---|
| Order / More Info | ITM2B Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|