| 產(chǎn)品詳情 |
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| Product Name | ALW-II-41-27 |
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| Description | A multi-kinase inhibitor; inhibits EphB2, EphA3, Kit, FMS, VEGFR2/KDR, FLT1, FGR, Src, Lyn, BMX, and Bcr-Abl in tyrosine kinase-transformed Ba/F3 cells (EC50s = 50s = 51 and 14 nM, respectively); inhibits wild-type and mutant RET kinases (IC50s = 24.7, 94.2, and 15.8 nM for wild-type, RETV804L, and RETV804M, respectively); reduces growth of NCI-H2286 and HCC-366 cancer cells (GI50s = 0.51 and 0.65 μM, respectively) and RAT1 cells transformed by RETC634R or RETM918T (IC50s = 44 and 56 nM, respectively); inhibits tumor growth in vivo in a mouse PDX model of EphA2-overexpressing TNBC, |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ALWII4127 ALWII41 ALWII-4127 EphB-2 EphA-3 2 Eph-B2 A2 A3 VEGFR-2 FLT-1 BaF3 F-3 DDR-2 H-2286 NCIH2286 HCC366 RAT-1 MDAMB231 MB231 MDAMB multikinase |
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| Gene, Accession, CAS # | CAS: 1186206-79-0 |
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| Catalog # | 25275-1 |
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| Price | |
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| Order / More Info | ALW-II-41-27 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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