| 產(chǎn)品詳情 |
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| Antigenic Specificity | IWS1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IWS1 Polyclonal Antibody. Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. |
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| Immunogen | n/a |
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| Other Names | IWS1-like protein, interacts with Spt6, protein IWS1 homolog |
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| Gene, Accession # | Entrez: 55677, 73473; Uniprot: Q8C1D8, Q96ST2 |
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| Catalog # | A304-609A-M |
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| Price | |
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| Order / More Info | IWS1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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