| 產(chǎn)品詳情 |
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| Antigenic Specificity | PARD3 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, frog, canine, monkey, rat, mouse |
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| Isotype | n/a |
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| Format | Alexa Fluor? 488 conjugate |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ICC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Mouse PARD3 polyclonal antibody for ICC. Partitioning defective 3 homolog (UniProt Q8TEW0; also known as ASIP, Atypical PKC isotype-specific-interacting protein, Bazooka, CTCL tumor antigen se2-5, Par-3 family cell polarity regulator alpha, Par-3 partitioning defective 3 homolog, PAR3-alpha, Protein phosphatase 1 regulatory subunit 118) is encoded by the PARD3 (also known as Baz, PAR3, PAR3A, PARD3A, PPP1R118) gene (Gene ID 56288) in human. Par3 is a PDZ (PSD95/Dlg/ZO-1) domain-containing membrane scaffold adapter protein that plays an important role in epithelial cell tight junction (TJ) formation and apico-basal polarity maintenance. Together with PAR6, atypical protein kinase C (aPKC), and the Rho GTPase CDC42, Par3 forms a complex that regulates cytoskeleton re-organization, post-golgi vesicle trafficking, microtubule network polarization, and asymmetric cell division. PAR6 interacts directly with aPKC isoforms iota/lambda and zeta to form the complex core. Recruitment of GTP-bound CDC42 to the PAR6-aPKC core induces aPKC phosphorylatioctivation by PAR6, and subsequent PAR3 binding. Another quaternary apical junctional complex (AJC), Willin-Par6-aPKC-Par3, has also been reported. In this case, the complex-associated aPKC functions to phosphorylate ROCK, resulting in ROCK dissociation from the AJC and thereby preventing excessive ROCK-dependent apical constriction. |
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| Immunogen | Fusion protein |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 56288, UniProt: Q8TEW0 |
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| Catalog # | CABT-B1566 |
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| Price | |
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| Order / More Info | PARD3 Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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