| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | CD223 |
|---|
| Clone | 11C3C65 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1, κ |
|---|
| Format | Alexa Fluor? 647 conjugate |
|---|
| Size | 100 tests |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry (FC) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Alexa Fluor? 647 anti-human CD223 (LAG-3). CD223, also known as LAG-3, is a 70 kD type I transmembrane glycoprotein that is involved in T-cell signaling. Similar to CD4, CD223 binds MHC class II, but with a higher affinity. CD223 negatively regulates T-cell activation. It is expressed by activated T-cells and natural killer cells (NKs), as well as regulatory T-cells. It is transiently expressed on the surface of activated T-cells in acute conditions but high expression is maintained under tolerizing conditions. CD223 deficiency results in reduced tumor growth. CD223 and PD-1 can act in synergy and reverse exhausted phenotypes, improve tumor rejection, and control viral load. |
|---|
| Immunogen | Human LAG-3 transfected cells. |
|---|
| Other Names | CD223, LAG-3, LAG3, lymphocyte-activation gene-3 |
|---|
| Gene, Accession # | Gene ID: 3902 |
|---|
| Catalog # | 369304 |
|---|
| Price | |
|---|
| Order / More Info | CD223 Antibody from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|