| 產(chǎn)品詳情 |
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| Antigenic Specificity | Xbp-1 (COOH terminus) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat, and weak reactive with mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 50 μl |
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| Concentration | n/a |
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| Applications | Western Blot (WB), ChIP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-XBP-1s. Reactivity: Human, Rat, and weak reactive with Mouse; recognizes the 54 kD form. Xbp-1 (X-box binding protein 1) is a ubiquitously expressed 29 kD member of the CREB/ATF transcription factor family, and a mammalian homologue of the yeast transcription factor Hac1. Xbp-1 regulates MHC class II genes by binding to the X-box promoter motif and can also bind to the enhancer in T cell leukemia virus type I promoter to increase viral protein expression by binding the viral transactivator. This transcription factor is essential for hepatocyte differentiation and can be upregulated by ER stress, IL-6, and IL-4. The PAX5 transcription factor downregulates Xbp-1; downregulation has been shown to correlate with tumor progression in prostate cancer. The Poly6195 antibody recognizes the C-terminal region of human and rat Xbp-1 and has been shown to be useful for Western blotting. |
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| Immunogen | Peptide |
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| Other Names | X-box binding protein 1 |
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| Gene, Accession # | Gene ID: 7494 |
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| Catalog # | 619501 |
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| Price | |
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| Order / More Info | Xbp-1 (COOH terminus) Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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