| 產(chǎn)品詳情 |
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| Antigenic Specificity | FBXO7 |
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| Clone | W16207A |
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| Host Species | Rat |
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| Reactive Species | human |
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| Isotype | IgG2a, κ |
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| Format | peroxidase (HRP) conjugate |
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| Size | 25 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | HRP anti-FBXO7. F-box only protein 7 (FBXO7) is involved in the ubiquitination process during protein degradation. FBXO7 is a subunit of the SCF (SKP1/cullin-1/F-box protein) complex. The scaffold proteins cullin-1 and SKP1, the RING subunit Rbx1 together with the substrate-recruiting subunit FBXO7 form a functional E3 ubiquitin ligase. FBXO7 is implicated in Parkinson’s disease. In addition to reduced proteasome activity, loss of FBXO7 in mice leads to Parkinsonism-like phenotype. Human FBXO7 is mainly localized to the nucleus, while the mutation observed in patients with parkinsonian-pyramidal syndrome leads to impaired nuclear localization of this protein. |
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| Immunogen | Human FBXO7 recombinant protein (1-250 a.a.) expressed in E. coli. |
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| Other Names | F-box only protein 7 |
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| Gene, Accession # | Gene ID: 25793 |
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| Catalog # | 853503 |
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| Price | |
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| Order / More Info | FBXO7 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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