| 產(chǎn)品詳情 |
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| Product Name | OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) protein (His tag) |
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| Description | Otubain 1 (OTUB1) belongs to the ovarian tumor (OUT) superfamily of predicted cysteine proteases and inhibits cytokine gene transcription in the immune system through its interaction with a ubiquitin protease and E3 ubiquitin ligase. OTUB1 is a highly specific ubiquitin iso-peptidase, it cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. OTUB1 is believed to work in specific ubiquitin-dependent pathways, possibly by providing an editing function of polyubiquitin chain growth. OTUB1 is a hydrolase that removes conjugated ubiquitin from proteins in vitro and may therefore have a significant regulatory role in the level of protein turnover by preventing degradation. Additionally, OTUB1 is a regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered impassive to antigen re-challenge and no longer respond to their cognate antigen. OTUB1 acts via its interaction with RNF128/GRAIL, which is an essential inductor of CD4 T-cell anergy Synonyms: Ubiquitin thioesterase OTUB1, Otubain-1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Ubiquitin-specific-processing protease OTUB1, Deubiquitinating enzyme OTUB1, OTUB1, OTB1, OTU1, HSPC263, MGC4584, FLJ20113, FLJ40710, MGC111158 |
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| Size | 5 μg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | fa19h07|otub1|wu:fa19h07|zgc:92839|MGC131231|AI850305|OTB1|OTU1 |
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| Gene, Accession, CAS # | Gene ID: 55611 |
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| Catalog # | ABIN807536 |
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| Order / More Info | OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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