| 產(chǎn)品詳情 |
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| Antigenic Specificity | IGF1 |
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| Clone | 1500102 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-IGF1. IGF-I, also known as insulin-like growth factor 1), was initially described in 1957 as a hormone that is important for child development, and also has anabolic effects in adults. It is a member of the IGF family that is comprised of three members: IGF-I, IGF-II, and insulin. IGF-I and IGF-II share approximately 50% similarity with insulin at the amino acid level. Human IGF-I is synthesized as a 191 amino acid prepro-IGF-I; pro-IGF-I is processed to the mature, active protein, and this procedure requires glucose regulating protein 94 (GRP94) that possesses chaperone activity towards IGF-I. Deletion of muscle GRP94 impairs muscle and body growth by inhibiting local production of IGF proteins. Seven IGF binding proteins have been described (IGFBP-1 to -7). IGFBPs extend the half-lives and regulate the availability of IGF-I and IGF-II. It has been described that IGFBP3 is the main circulating binding protein for IGFs in serum. 75% of circulating IGF-I and IGF-II bind to IGFBP3 and the co-carrier acid labile subunit (ALS). IGF-I binds to three receptors, and the binding to IGFIR promotes cell proliferation, survival, differentiation, and migration. IGF-I deficiency is associated with growth hormone insensitivity syndrome (GHIS), which is also called Laron syndrome, liver cirrhosis, age-related cardiovascular, neurological diseases, and intrauterine growth restriction. |
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| Immunogen | Recombinant Human IGF-I, amino acids (Gly49-Ala118) (Accession# PO05019), expressed in E. coli |
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| Other Names | Insulin-Like Growth Factor 1, IGF-1, Mechano Growth Factor, Somatomedin-C, IGF-I, MGF, Insulin-Like Growth Factor IA, Insulin-Like Growth Factor IB, Nonsuppressible insulin-like activity I (NSILA-I) |
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| Gene, Accession # | Gene ID: 3479 |
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| Catalog # | 680402 |
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| Price | |
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| Order / More Info | IGF1 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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