| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Product Name | XMD 8-92 |
|---|
| Description | ERK5 (BMK1) and BRD4 inhibitor (Kd values are 80 and 190 nM, respectively). Also inhibits DCAMKL2, PLK4 and TNK1 (Kd values are 190, 600 and 890 nM). Blocks growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. Also reduces BMK1-dependent transactivating activity of MEF2C. Inhibits proliferation in a variety of cancer cell lines; blocks tumor cell proliferation and tumor-associated angiogenesis. Purity 98%. MW (observed): 474.55 |
|---|
| Size | 50 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
|---|
| Gene, Accession, CAS # | CAS: 1234480-50-2 |
|---|
| Catalog # | 4132/50 |
|---|
| Price | |
|---|
| Order / More Info | XMD 8-92 from TOCRIS BIOSCIENCE
|
|---|
| Product Specific References | PubMed: 24762669, 25855966, 29416614 |
|---|
| 產(chǎn)品資料 |
|
|