| 產(chǎn)品詳情 |
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| Antigenic Specificity | NKX2-1 |
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| Clone | 14D3A28 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a, κ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-NKX2-1 (TTF-1). NKX2-1 is a homeodomain containing transcription factor, responsible for regulating normal development and maintaining physiological functions of the lung, thyroid, and central nervous system. NKX2-1 appears to play a dual role in lung carcinogenesis. In lung tumors, NKX2-1 expression is significantly amplified. NKX2-1 is required for survival of lung adenocarcinoma and considered as a lineage survival oncogene. However, loss of NKX2-1 promotes metastasis in mouse lung adenocarcinoma. Lower NKX2-1 expression in human lung carcinoma have worse prognoses, suggesting that NKX2-1 inhibits tumor metastasis and acts as a tumor suppressor. |
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| Immunogen | Partial NKX2-1 recombinant protein (1-122 aa) |
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| Other Names | NK-2, TEBP, NKX2A, TITF1, TTF-1, NKX2.1, TTF1 NKX2 |
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| Gene, Accession # | Gene ID: 7080 |
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| Catalog # | 655402 |
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| Price | |
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| Order / More Info | NKX2-1 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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