| 產(chǎn)品詳情 |
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| Antigenic Specificity | MBP (aa 100-140) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat, mouse |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).Subcellular location: Myelin membrane, Peripheral membrane protein, Cytoplasmic side. Note: Cytoplasmic side of myelin.Tissue specificity: MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Also known as: MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein. |
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| Immunogen | A synthetic peptide from aa region 100-140 of human MBP conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
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| Other Names | Mbps|MBP|mMBP|mMBP-1 |
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| Gene, Accession # | Gene ID: 4155,19074,24547 |
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| Catalog # | ABIN350504 |
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| Price | |
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| Order / More Info | MBP (aa 100-140) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 16079912, 2425357, 7504278, 2427738, 2442403 |
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