| 產(chǎn)品詳情 |
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| Product Name | Caspase-8 (Human) ELISA Kit |
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| Description | Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target |
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| Size | 100 assays |
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| Concentration | n/a |
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| Applications | This ELISA kit is used for quantitative measurement of Caspase-8 in human serum, plasma, tissue homogenates and other biological fluids. |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | E4290-100 |
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| Order / More Info | Caspase-8 (Human) ELISA Kit from BIOVISION, INC. |
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| Product Specific References | n/a |
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