| 產(chǎn)品詳情 |
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| Antigenic Specificity | Amphiphysin |
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| Clone | N8-2 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 μg, Western Blot: 0.1 μg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Amphiphysin Monoclonal Antibody (N8-2). Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome. |
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| Immunogen | n/a |
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| Other Names | AMPH; AMPH1; Stiff Man syndrome with breast cancer 128kDa autoantigen |
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| Gene, Accession # | Entrez: 218038, 273, 60668; Uniprot: O08838, P49418, Q7TQF7 |
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| Catalog # | MA5-17205 |
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| Price | |
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| Order / More Info | Amphiphysin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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