| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Product Name | L-168,049 |
|---|
| Description | Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC50 > 1 μM). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC50 = 41 nM), and in murine liver membranes. Orally active in vivo. Purity 99%. MW (observed): 467.79 |
|---|
| Size | 50 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 4-[3-(5-Bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine |
|---|
| Gene, Accession, CAS # | CAS: 191034-25-0 |
|---|
| Catalog # | 2311/50 |
|---|
| Price | |
|---|
| Order / More Info | L-168,049 from TOCRIS BIOSCIENCE
|
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|