| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Product Name | CD437 |
|---|
| Description | CD437 is the adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively). CD437 is cytotoxic to the acute myeloid leukemia cell line NB4 (EC50 = 0.17 μM), inducing DNA damage by producing DNA double strand breaks. CD437 also induces cell cycle arrest and apoptosis in various other cancer cells including melanoma, breast, non-small lung, and prostate cancer cells through RAR-dependent and -independent signaling pathways. Treatment of mouse embryonic fibroblasts (MEFs) with CD437 early in the reprogramming process significantly increases reprogramming efficiency up to 20- |
|---|
| Size | 25 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 6-?(4-?hydroxy-?3-?tricyclo[3.3.1.13,?7]dec-?1-?ylphenyl)-?2-?naphthalenecarboxylic acid; AHPN |
|---|
| Gene, Accession, CAS # | CAS: 125316-60-1 |
|---|
| Catalog # | 2636-25 |
|---|
| Price | |
|---|
| Order / More Info | CD437 from BIOVISION, INC. |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|