| 產(chǎn)品詳情 |
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| Antigenic Specificity | LIN28A |
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| Clone | 14E6-4E6 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | ChIP assay: 1-3 μL, Flow Cytometry: 1:100, Immunocytochemistry: 1:50-1:200, Immunofluorescence: 1:50 - 1:200, Immunohistochemistry (Paraffin): 1:20-1:200, Immunoprecipitation: 5 μg, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LIN28A Monoclonal Antibody (14E6-4E6). LIN28A/B are expressed in various cancers and ES cells. LIN28 is a cytoplasmic protein, that acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. LIN28 is a negative regulator of microRNA (miRNA) biogenesis by specifically binding the precursor of let-7 (pre-let-7). Let-7 miRNAs have been implicated in repression of oncogenes such as ras and myc. LIN28 expression decreases during differentiation of ES cells or upon induction of neuronal differentiation by retinoic acid. |
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| Immunogen | n/a |
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| Other Names | Lin-28 homolog A (C. elegans), RNA-binding protein LIN-28, LIN28A, CSDD1, Zinc finger CCHC domain-containing protein 1, ZCCHC1 |
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| Gene, Accession # | Entrez: 79727, 83557; Uniprot: Q8K3Y3, Q9H9Z2 |
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| Catalog # | MA1-016 |
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| Price | |
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| Order / More Info | LIN28A Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 26352799 |
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| 產(chǎn)品資料 |
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