| 產(chǎn)品詳情 |
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| Antigenic Specificity | PEN2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: 1:50-1:100, Western Blot: 1:1000-1:2500 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PEN2 Polyclonal Antibody. Presnilin (PS1/PS2) complexes are responsible for the intramembrane gamma-secretase cleavage of the beta-amyloid precursor protein. Presenilin enhancer 2 (PEN2) is an essential cofactor involved physically interacting with PS1 and is necessary for gamma-secretase activity. Endogenous PEN2 preferentially interacts with PS1 holoprotein. Down-regulation of PEN2 expression abolishes the endoproteolysis of PS1 and overexpression promotes the production of PS1 fragments. |
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| Immunogen | n/a |
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| Other Names | Gamma-secretase subunit PEN-2, hematopoietic stem/progenitor cells protein MDS033, MDS033, MSTP064, presenilin enhancer 2, Presenilin enhancer protein |
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| Gene, Accession # | Entrez: 55851, 66340; Uniprot: Q9CQR7, Q9NZ42 |
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| Catalog # | PA3-16762 |
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| Price | |
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| Order / More Info | PEN2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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