| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | PEN2 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | bovine, canine, equine, human, marsupial, mouse, rat |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 ug |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blot: 3-7 μg/mL |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | PEN2 Polyclonal Antibody. Presenilin enhancer protein 2 (PEN-2) is a part of a gamma-secreted complex which catalyses the final cleavage of amyloid precursor protein to generate the toxic amyloid beta protein, the major component of plaque in the brains of Alzheimer disease patients. It is an essential subunit of the gamma-secretase complex, and an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). And probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. |
|---|
| Immunogen | n/a |
|---|
| Other Names | MDS033, MSTP064, PEN-2, PEN2, gamma-secretase subunit PEN-2, hematopoietic stem/progenitor cells protein MDS033 |
|---|
| Gene, Accession # | Entrez: 100051536, 292788, 476479, 493993, 55851, 66340; Uniprot: Q5G235, Q6QI68, Q9CQR7, Q9NZ42 |
|---|
| Catalog # | PA5-23447 |
|---|
| Price | |
|---|
| Order / More Info | PEN2 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|