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| Antigenic Specificity | MBD1 |
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| Clone | OTI2H5 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 μl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:500, Western Blot: 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MBD1 Monoclonal Antibody (OTI2H5). DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also kno |
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| Immunogen | n/a |
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| Other Names | Methyl CpG Binding Domain Protein 1 |
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| Gene, Accession # | Entrez: 4152; Uniprot: Q9UIS9 |
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| Catalog # | MA5-27525 |
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| Price | |
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| Order / More Info | MBD1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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