| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) |
|---|
| Clone | SEC21 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1 |
|---|
| Format | supernatant |
|---|
| Size | 1 mL |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blotting (WB) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Cadherins constitute a family of transmembrane glycoproteins involved in Ca 2+ -dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4), whereas kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. One of the best characterized cadherins is E-cadherin, a 120 kD transmembrane glycoprotein consisting of an 80 kD extracellular and a 40 kD transmembrane and cytoplasmic part. The extracellular domains of E-cadherin are responsible for calcium binding which allows for homophilic interaction with other E-cadherin molecules on the same cell and neighbouring cells. In addition, E-cadherin can interact heterophilically with integrin alpha E beta 7 . The cytoplasmic domain of E-cadherin is linked to the actin cytoskeleton through the associated cytoplasmic catenin proteins, thus establishing a complex localized to adherens junctions. In carcinomas E-cadherin is frequently downregulated, which is consistent with its function of an invasion suppressor in normal epithelia. |
|---|
| Immunogen | SEC21 is a mouse monoclonal IgG1 antibody obtained by fusion of NS0 mouse myeloma cells with spleen cells from a mouse immunized with the synthetic peptide corresponding to amino acids 30-43 of mature human E-cadherin coupled to keyhole limpet hemocyanin. |
|---|
| Other Names | E-Cad|E-cadherin|XB-cadherin|XBcad|XTCAD-1|b-cadherin|cadherin-1|cdh1-a|cdhc-A|cdhp|hjmd|l-cam|lcam|pcad|uvo|uvomorulin|xb-cad|xcdh1|Arc1|AA960649|E-cad|Ecad|L-CAM|UVO|Um|Arc-1|CD324|CDHE|ECAD|LCAM|arc-1|cd324|cdhe|ecad|cdh1|si:dz180o5.2 |
|---|
| Gene, Accession # | Gene ID: 999 |
|---|
| Catalog # | ABIN335290 |
|---|
| Price | |
|---|
| Order / More Info | Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|