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| Antigenic Specificity | GRP78 |
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| Clone | 4E3 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:200 - 1:1000, Western Blot: 1:500 - 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | GRP78 Monoclonal Antibody (4E3). GRP78 is a 78 kDa glucose regulated protein that belongs to the family of heat shock proteins that include HSP70. GRP78 is a resident protein of the endoplasmic reticulum (ER) and associates transiently with a variety of newly synthesized secretory and membrane proteins. GRP78 may also interact with mutant and misfolded proteins, marking them for degradation. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C-terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP94) and protein disulfide isomerase (PDI). The KDEL signal is recognized by the KDEL receptor and this interaction ensures recycling of escaped ER proteins back to the ER. GRP78's involvemen |
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| Immunogen | n/a |
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| Other Names | BIP; Heat Shock 70 kDa protein 5; GRP-78; 78 kDa glucose-regulated protein; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; immunoglobulin heavy chain-binding protein |
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| Gene, Accession # | Entrez: 14828, 3309; Uniprot: P11021, P20029 |
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| Catalog # | MA5-15619 |
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| Price | |
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| Order / More Info | GRP78 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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