| 產(chǎn)品詳情 |
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| Antigenic Specificity | Fe65 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 2 μg/mL, Immunofluorescence: 2 μg/mL, Western Blot: 1-2 μg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Fe65 Polyclonal Antibody. The major transcript of the Fe65 gene is a neuron-specific mRNA that encodes a nuclear protein whose amino-terminal domain strongly activates the transcription of reporter genes. Fe65 has been implicated in a regulatory and cell signaling mechanism because it contains two different motifs involved in protein binding; a WW domain (a variant of Src homology 3 domains) and a phosphotyrosine interaction domain (PID). Interestingly, the PID domain binds to the same motif present in the conserved cytoplasmic domains of the beta PP and beta PP-like proteins. RNA analyses revealed that Fe65 is predominantly expressed in the brain and in the regions most affected by Alzheimer's disease-associated neuropathology. |
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| Immunogen | n/a |
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| Other Names | APBB1 |
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| Gene, Accession # | Entrez: 11785, 29722, 322; Uniprot: O00213, P46933, Q9QXJ1 |
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| Catalog # | PA1-752 |
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| Price | |
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| Order / More Info | Fe65 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 17170108, 17904250 |
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| 產(chǎn)品資料 |
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