| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | Lactadherin |
|---|
| Clone | polyclonal |
|---|
| Host Species | Goat |
|---|
| Reactive Species | mouse |
|---|
| Isotype | n/a |
|---|
| Format | biotin conjugate |
|---|
| Size | 50 μg |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA Detection |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Biotin anti-mouse Lactadherin. Lactadherin, a novel adhesion molecule, also known as MFG-E8, is a widely distributed glycoprotein (~50 kD) that has been found in macrophages, dendritic cells, vascular smooth muscle cells, astrocytes, microglia, breast carcinioma cells, and also in breast milk and around blood vessels. Lactadherin contains an N-terminal EGF-like motif with an inserted RGD cell adhesion sequence; it also contains a C-terminal sequence sharing homology with the discoidin family of lectin domains, including the phospholipid-binding domains of blood clotting factors V and VIII. Lactadherin promotes RGD-dependent cell attachment of a variety of cell types, but most notably of cells that express the integrin heterodimer, alpha vβ3. The C1/C2 domain binds specifically to phosphatidylserine. Mounting evidence has shown that Lactadherin plays a far more important role than just protecting the newborn, a function originally identified. Lactadherin is anticoagulant by blocking phosphatidylserine-containing membrane sites for blood coagulation proteins. It is involved in cell death by its ability to recognize specifically phosphatidylserine exposed on apoptotic cells. Lactadherin is also crucial in VEGF-dependent neovascularization and has been identified as an important target for the modulation of neovascularization. In addition, Lactadherin was identified as a novel target for radioimmunotherapy in breast cancer, and is also important in the initiation and/or progression of Alzheimer's disease. |
|---|
| Immunogen | 293E cells expressed recombinant mouse Lactadherin |
|---|
| Other Names | Lactadherin, Milk fat globule-EGF factor 8, MFG-E8, MFGE-8, MFGE8 MFGM, Sperm surface protein SP47, MP47 PAS-6/7, bovine-associated mucoprotein, BA-46, P47 |
|---|
| Gene, Accession # | Gene ID: 17304 |
|---|
| Catalog # | 518603 |
|---|
| Price | |
|---|
| Order / More Info | Lactadherin Antibody from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|