| 產(chǎn)品詳情 |
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| Product Name | Multidrug Efflux Transporter (MDR1/P-gp) Ligand Screening Kit |
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| Description | P-glycoprotein (P-gp, Multidrug Resistance Protein 1 (MDR1), EC 3.6.3.44) is a member of the ATP-binding cassette (ABC) ATPase superfamily of transmembrane transporter proteins. P-gp has an extremely broad substrate specificity and is capable of transporting a vast array of neutral and anionic lipophilic molecules. P-gp strongly affects the oral absorption, tissue distribution and excretion of many drugs and prevents certain lipophilic drugs from penetrating the blood brain barrier. Overexpression of P-gp confers tumor cells with resistance to chemically and pharmacologically distinct chemotherapeutic drugs (such as doxorubicin, vincristine and paclitaxel) by actively pumping them out of cells. Induction of P-gp expression is a frequent cau |
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| Size | 100 Assays |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | K507-100 |
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| Order / More Info | Multidrug Efflux Transporter (MDR1/P-gp) Ligand Screening Kit from BIOVISION, INC. |
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| Product Specific References | n/a |
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