| 產(chǎn)品詳情 |
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| Antigenic Specificity | CBFA2T2 |
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| Clone | 2C10 |
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| Host Species | Recombinant Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b, κ |
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| Format | purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA, IHC-F, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mouse Anti-CBFA2T2 Recombinant Antibody (2C10). This product is antibody recognizes CBFA2T2. The antibody 2C10 immunoassay techniques such as: ELISA, IHC-F, WB. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to |
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| Immunogen | Partial recombinant corresponding to aa201-304 from CBFA2T2 (NP_001028171.1) with GST tag. MW of the GST tag alone is 26kD |
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| Other Names | CBFA2/RUNX1 Translocation Partner 2; Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 2; Myeloid Translocation-Related Protein 1; ETO Homologous On Chromosome 20; MTG8-Related Protein 1; MTG8-Like Protein; MTGR1; |
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| Gene, Accession # | Gene ID: 9139, UniProt: O43439 |
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| Catalog # | CBMAB-C4745-LY |
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| Price | |
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| Order / More Info | CBFA2T2 Antibody from CREATIVE BIOLABS |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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