| 產(chǎn)品詳情 |
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| Antigenic Specificity | C5a/C5a(desArg)/C5 |
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| Clone | G25/2 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, κ |
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| Format | purified, azide-free |
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| Size | 500 μg |
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| Concentration | n/a |
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| Applications | ELISA Detection, Western Blot (WB), IP, Neut |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LEAF? Purified anti-human C5a/C5a(desArg)/C5. C5, complement component 5, is a protein involved in the complement system. It is cleaved into C5a and C5b by the C3/C5 convertase. The smaller fragment C5a is an anaphylatoxin and? is released into the fluid surroundings. C5a is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). C5a contains 74 amino acids and is rapidly metabolised by a serum enzyme, carboxypeptidase B to a 73 amino acid form, C5a des-Arg. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. |
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| Immunogen | Human C5a |
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| Other Names | C5a, C5a desarg, C5, complement component 5, complement C5a |
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| Gene, Accession # | Gene ID: 727 |
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| Catalog # | 518304 |
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| Price | |
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| Order / More Info | C5a/C5a(desArg)/C5 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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