| 產(chǎn)品詳情 |
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| Product Name | Recombinant Human R-Spondin-3 Protein |
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| Description | The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization and resulting accumulation of the intracellular signaling protein, β-catenin. This activity effectively activates and increases the subsequent nuclear signaling of β-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/β-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations. Recombinant human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues. Due to glycosylation, R-Spondin-3 migrates at an apparent molecular weight of approximately 37.0 kDa by SDS PAGE analysis under reducing conditions. |
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| Size | Various Sizes |
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| Concentration | n/a |
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| Applications | Cell Culture |
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| Other Names | R-spondin-3;Protein with TSP type-1 repeat;hPWTSR;Roof plate-specific spondin-3;hRspo3;Thrombospondin type-1 domain-containing protein 2;RSPO3;PWTSR, THSD2; PWTSR, THSD2, Roof, plate-specific spondin-3, RSPO3 |
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| Gene, Accession, CAS # | RSPO3, UniProt: Q9BXY4 |
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| Catalog # | PROTQ9BXY4-1 |
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| Order / More Info | Recombinant Human R-Spondin-3 Protein from BOSTER BIO |
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| Product Specific References | n/a |
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