| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | Human BACE (C-terminal, aa 485-501) |
|---|
| Clone | polyclonal |
|---|
| Host Species | Goat |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | unconjugated |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA, IHC, WB |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Goat Anti-Human BACE (C-terminal) polyclonal antibody for ELISA, IHC, WB. Alzheimer`s disease (AD) is characterized by the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of the 4-kD amyloid β-peptide (Aβ). Aβ generation is initiated by proteolytic cleavage of the amyloid precursor protein (APP) at the N-terminal of Aβ by β-secretase. The Aβ peptide is then released by proteolytic cleavage at its C-terminus by 8-secretase. Because both these proteases are prime candidates for therapeutic intervention, an intense search has been underway to identify these two enzymes. β-secretase is a transmembrane aspartic-protease (Asp2), referred to as BACE or memapsin 2, has been characterized and shown to have all the properties of β-secretase. Four groups in all have now confirmed that BACE (or memapsin 2) is a convincing candidate for β-secretase. |
|---|
| Immunogen | Peptide (CLRQQHDDFADDISLLK) |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | Gene ID: 23621, UniProt: P56817 |
|---|
| Catalog # | CABT-L524 |
|---|
| Price | |
|---|
| Order / More Info | Human BACE (C-terminal, aa 485-501) Antibody from CREATIVE DIAGNOSTICS |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
|