| 產(chǎn)品詳情 |
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| Antigenic Specificity | TCF8 |
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| Clone | P82A8A6 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-TCF8 (ZEB1). TCF-8, also named ZEB1, belongs to the ZEB family of transcription factors characterized by the presence of 2 zinc finger clusters and are responsible for the binding to specific DNA sequences named E-boxes. By recruiting co-suppressors or co-activators through CID, SID or CBD, TCF-8 can either downregulate or upregulate the expression of its target genes.TCF-8 promotes tumor invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) in carcinoma cells. It is associated with aggressive behaviour, metastasis, treatment resistance and poor prognosis in different tumour types, including breast, pancreatic, prostate and lung cancer. |
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| Immunogen | Purified recombinant fragment of human ZEB1 (aa 967-1108) expressed in E. Coli. |
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| Other Names | Zinc finger E-box-binding homeobox 1, Negative regulator of IL2, Transcription factor 8, ZEB1, BZP, AREB6 |
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| Gene, Accession # | Gene ID: 6935 |
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| Catalog # | 685602 |
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| Price | |
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| Order / More Info | TCF8 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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