| 產(chǎn)品詳情 |
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| Antigenic Specificity | TCF1 |
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| Clone | 7F11A10 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, κ |
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| Format | peroxidase (HRP) conjugate |
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| Size | 100 μl |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Direct-Blot? HRP anti-TCF1 (TCF7). TCF1 is the first identified member of the T-cell-specific transcription factor family.? It plays an important role in T cell development and differentiation. TCF1 is inactivated by association with the transcriptional repressor TLE proteins. During Wnt signaling, the transcriptional coactivator CTNNB1 accumulates and, in turn, replaces the transcriptional repressor associated with TCF1. Interaction with CTNNB1 results in transactivation of TCF1 target genes. Deletion of TCF1 causes massive apoptosis of double positive thymocyte, suggesting that TCF1 is required for thymocyte survival during T cell development. In addition to its function in thymus, TCF1 promotes T cell differentiation to Th2 cells in the periphery through transcriptional activation of GATA3. |
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| Immunogen | Partial TCF1 recombinant protein (116-334 aa) |
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| Other Names | T-cell-specific transcription factor 1 (TCF-1), transcription factor 7 (TCF-7) |
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| Gene, Accession # | Gene ID: 6932 |
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| Catalog # | 655210 |
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| Price | |
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| Order / More Info | TCF1 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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