| 產品詳情 |
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| Product Name | AMD 3100 octahydrochloride |
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| Description | Highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo. Attenuates cocaine place preference and locomotor stimulation in rats. Attenuates microglial activation neurological function after ischemic stroke in mice. MW (observed): 794.48. |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride. JM 3100, Plerixafor |
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| Gene, Accession, CAS # | CAS: 155148-31-5 |
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| Catalog # | 3299/50 |
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| Order / More Info | AMD 3100 octahydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 21131351, 21224081, 22241961, 23706740, 23993096, 24587052, 24948818, 25403444, 26020638, 26214690, 26408255, 28432337, 29340033, 29453386 |
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