| 產(chǎn)品詳情 |
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| Antigenic Specificity | ZAP-70 |
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| Clone | A16043B |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, κ |
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| Format | Alexa Fluor? 647 conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | Intracellular Staining for Flow Cytometry (ICFC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Alexa Fluor? 647 anti-ZAP-70. ZAP-70 is a 70kD protein expressed near the surface membrane of T-cells and NK cells. It is part of the intracellular signaling mechanism of the T-cell receptor, and plays integral role in T-cell signaling where it interacts with CD3-ζ to phosphorylate transmembrane protein LAT, which facilitates the binding of many signaling proteins. ZAP-70 plays a key role in the activation of T-cells, and their subsequent proliferation, differentiation, and production of cytokines in response to varied stimuli. It is used clinically as a prognostic marker helping differentiate the various types of chronic lymphocytic leukemia (CLL). |
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| Immunogen | Human ZAP-70 peptide phosphorylated at Y493. Complete Freund's adjuvant. |
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| Other Names | Zeta chain of TCR associated protein kinase 70 |
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| Gene, Accession # | Gene ID: 7535, 22637 |
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| Catalog # | 693508 |
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| Price | |
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| Order / More Info | ZAP-70 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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