| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | CD49d |
|---|
| Clone | 9F10 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human, African green, baboon, cat , cow, chimpanzee, common marmoset, cynomolgus, dog , horse , rhesus, sheep , squirrel monkey |
|---|
| Isotype | IgG1, κ |
|---|
| Format | purified |
|---|
| Size | 100 μg |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry (FC), CyTOF? |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Purified anti-human CD49d (MaxPar? Ready). CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells. |
|---|
| Immunogen | n/a |
|---|
| Other Names | Integrin α4 chain, VLA-4 α chain, α4 integrin |
|---|
| Gene, Accession # | Gene ID: 3676 |
|---|
| Catalog # | 304319 |
|---|
| Price | |
|---|
| Order / More Info | CD49d Antibody from BIOLEGEND |
|---|
| Product Specific References | PubMed: 18941119,20233972,21765017 |
|---|
| 產(chǎn)品資料 |
|
|