| 產(chǎn)品詳情 |
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| Product Name | DHFR, 1-187aa, Mouse, His tag, E.coli (Bioactivity Validated) |
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| Description | Purity: > 95% by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.. Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. DHFR catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, and it is essential for the synthesis of thymidylate, purines and several amino acids. Expression of methotrexate (MTX)-resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive. Recombinant mouse DHFR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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| Size | 0.5mg, 100ug, 20ug |
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| Concentration | n/a |
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| Applications | Enzyme activity |
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| Other Names | Dihydrofolate reductase, EC 1.5.1.3 |
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| Gene, Accession, CAS # | NP 034179 |
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| Catalog # | ATGP0912 |
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| Price | |
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| Order / More Info | DHFR, 1-187aa, Mouse, His tag, E.coli (Bioactivity Validated) from ATGen |
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| Product Specific References | n/a |
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