| 產(chǎn)品詳情 |
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| Antigenic Specificity | Caspase 3 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | Protein A purified |
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| Size | 5 ug (trial size), 20 ug (trial size), 100 ug, 200 ug |
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| Concentration | n/a |
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| Applications | FACS, ICC, IF, IHC-P, P-ELISA, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit polyclonal antibody to caspase 3 is also known as apopain and whose expression can be detected in the tonsils and skeletal muscles but it is highly expressive in the spleen and kidney. It is found in the death-inducing signaling complex in plasma membrane. This protein is extensively involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp-|-Gly-217 bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. |
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| Immunogen | KLH conjugated synthetic peptide derived between 33178 amino acids of human Caspase 3 |
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| Other Names | A830040C14Rik, apop, Apopain, Apopain precursor, CASP3, Casp3a, Caspase 3 apoptosis related cysteine protease, Caspase 3 p12 subunit, Caspase 3 p17 subunit, Caspase3, CPP32, CPP32B, Cysteine protease CPP32, Human cysteine protease CPP32 isoform alpha mRNA complete cds, ICE3, LICE, PARP cleavage protease, SCA-1, SREBP cleavage activity 1, Yama protein |
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| Gene, Accession # | Gene ID: 836, NCBI: NP_004337.21; NM_004346.31, UniProt: P42574 (Human); P70677 (Mouse); P55213 (Rat) |
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| Catalog # | orb10237 |
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| Price | |
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| Order / More Info | Caspase 3 Antibody from BIORBYT LTD. |
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| Product Specific References | n/a |
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