| 產(chǎn)品詳情 |
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| Product Name | Pin1, Recombinant, Human (Peptidyl-prolyl cis/trans Isomerase NIMA-interacting 1, PPIase) |
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| Description | Purity ~95% (RP-HPLC, SDS-PAGE). Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA, PLK I, Wee, and Myt1 kinases), several transcription factors like b-Catenin, c-Jun, and the tumor suppressor protein p53, and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1. Source: Recombinant protein corresponding to human Pin1, a single, non-glycosylated polypeptide chain containing 163aa, expressed in E. coli. Molecular Weight: ~1 |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 209140 |
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| Order / More Info | Pin1, Recombinant, Human (Peptidyl-prolyl cis/trans Isomerase NIMA-interacting 1, PPIase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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