| 產(chǎn)品詳情 |
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| Product Name | PYR41 |
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| Description | An irreversible inhibitor of ubiquitin-activating enzyme (E1; IC50 = 50 = 6.4 μM); selective for E1 over E2 but does inhibit autoubiquitination of the HECT domain E3 Nedd4 at 50 μM; inhibits proteasome-dependent and -independent ubiquitination and protein degradation at 50 μM; preferentially induces apoptosis of E1A-transformed RPE cells expressing wild-type p53 over non-transformed RPE cells at 1-20 μM; also increases net cellular sumoylation and irreversibly cross-links proteins such as JAK2 and Bcr-Abl |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PYR-41 E-1 2 3 auto-ubiquitination NFκB TRAF-6 p-53 JAK-2 Bcrabl Tumor necrosis factor janus kinase 2 |
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| Gene, Accession, CAS # | CAS: 418805-02-4 |
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| Catalog # | 15226-10 |
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| Price | |
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| Order / More Info | PYR41 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 產(chǎn)品資料 |
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